TY  - JOUR
A1  - Ebel, Kenny
A1  - Bald, Ilko
T1  - Low-energy (5-20 eV) electron-induced single and double strand breaks in well-defined DNA sequences
T2  - The journal of physical chemistry letters / American Chemical Society
N2  - Ionizing radiation is used in cancer radiation therapy to effectively damage the DNA of tumors. The main damage is due to generation of highly reactive secondary species such as low-energy electrons (LEEs). The accurate quantification of DNA radiation damage of well-defined DNA target sequences in terms of absolute cross sections for LEE-induced DNA strand breaks is possible by the DNA origami technique; however, to date, it is possible only for DNA single strands. In the present work DNA double strand breaks in the DNA sequence 5'-d(CAC)(4)/5'd(GTG)(4) are compared with DNA single strand breaks in the oligonucleotides 5'-d(CAC)(4) and 5'-d(GTG)(4) upon irradiation with LEEs in the energy range from 5 to 20 eV. A maximum of strand break cross section was found around 7 and 10 eV independent of the DNA sequence, indicating that dissociative electron attachment is the underlying mechanism of strand breakage and confirming previous studies using plasmid DNA.
Y1  - 2022
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/57398
SN  - 1948-7185
VL  - 13
IS  - 22
SP  - 4871
EP  - 4876
PB  - American Chemical Society
CY  - Washington
ER  -