TY  - JOUR
A1  - Omranian, Sara
A1  - Angeleska, Angela
A1  - Nikoloski, Zoran
T1  - Efficient and accurate identification of protein complexes from protein-protein interaction networks based on the clustering coefficient
T2  - Computational and structural biotechnology journal
N2  - Identification of protein complexes from protein-protein interaction (PPI) networks is a key problem in PPI mining, solved by parameter-dependent approaches that suffer from small recall rates. Here we introduce GCC-v, a family of efficient, parameter-free algorithms to accurately predict protein complexes using the (weighted) clustering coefficient of proteins in PPI networks. Through comparative analyses with gold standards and PPI networks from Escherichia coli, Saccharomyces cerevisiae, and Homo sapiens, we demonstrate that GCC-v outperforms twelve state-of-the-art approaches for identification of protein complexes with respect to twelve performance measures in at least 85.71% of scenarios. We also show that GCC-v results in the exact recovery of similar to 35% of protein complexes in a pan-plant PPI network and discover 144 new protein complexes in Arabidopsis thaliana, with high support from GO semantic similarity. Our results indicate that findings from GCC-v are robust to network perturbations, which has direct implications to assess the impact of the PPI network quality on the predicted protein complexes. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
KW  - Protein complexes
KW  - Protein-protein interaction
KW  - Network clustering
KW  - Species comparison
Y1  - 2021
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/63261
SN  - 2001-0370
VL  - 19
SP  - 5255
EP  - 5263
PB  - Elsevier
CY  - Amsterdam
ER  -