TY  - JOUR
A1  - Kaminski, Roland
A1  - Schaub, Torsten H.
A1  - Siegel, Anne
A1  - Videla, Santiago
T1  - Minimal intervention strategies in logical signaling networks with ASP
T2  - Theory and practice of logic programming
N2  - Proposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.
Y1  - 2013
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/34883
SN  - 1471-0684
VL  - 13
SP  - 675
EP  - 690
PB  - Cambridge Univ. Press
CY  - New York
ER  -