TY  - JOUR
A1  - Bornhorst, Julia
A1  - Ebert, Franziska
A1  - Meyer, Sören
A1  - Ziemann, Vanessa
A1  - Xiong, Chan
A1  - Guttenberger, Nikolaus
A1  - Raab, Andrea
A1  - Baesler, Jessica
A1  - Aschner, Michael
A1  - Feldmann, Jörg
A1  - Francesconi, Kevin
A1  - Raber, Georg
A1  - Schwerdtle, Tanja
T1  - Toxicity of three types of arsenolipids
T2  - Metallomics
N2  - Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.
Y1  - 2020
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/51500
SN  - 1756-591X
SN  - 1756-5901
VL  - 12
IS  - 5
SP  - 794
EP  - 798
PB  - Oxford University Press
CY  - Cambridge
ER  -