TY  - JOUR
A1  - Taleshi, Mojtaba S.
A1  - Seidler-Egdal, Rune K.
A1  - Jensen, Kenneth Bendix
A1  - Schwerdtle, Tanja
A1  - Francesconi, Kevin A.
T1  - Synthesis and Characterization of Arsenolipids: Naturally Occurring Arsenic Compounds in Fish and Algae
T2  - Organometallics
N2  - Arsenic-containing lipids (arsenolipids) are natural products present in fish and algae. Because these compounds occur in foods, there is considerable interest in their human toxicology. We report the synthesis and characterization of seven arsenic-containing lipids, including six natural products. The compounds comprise dimethylarsinyl groups attached to saturated long-chain hydrocarbons (three compounds), saturated long-chain fatty acids (two compounds), and monounsaturated long chain fatty acids (two compounds). The arsenic group was introduced through sodium dimethylarsenide or bis(dimethylarsenic) oxide. The latter route provided higher and more reproducible yields, and consequently, this pathway was followed to synthesize six of the seven compounds. Mass spectral properties are described to assist in the identification of these compounds in natural samples. The pure synthesized arsenolipids will be used for in vitro experiments with human cells to test their uptake, biotransformation, and possible toxic effects.
Y1  - 2014
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/37989
SN  - 0276-7333
SN  - 1520-6041
VL  - 33
IS  - 6
SP  - 1397
EP  - 1403
PB  - American Chemical Society
CY  - Washington
ER  -