TY - JOUR
A1 - Grebenkov, Denis S.
A1 - Metzler, Ralf
A1 - Oshanin, Gleb
T1 - Strong defocusing of molecular reaction times results from an interplay of geometry and reaction control
T2 - Communications Chemistry
N2 - Textbook concepts of diffusion-versus kinetic-control are well-defined for reaction-kinetics involving macroscopic concentrations of diffusive reactants that are adequately described by rate-constantsâ€”the inverse of the mean-first-passage-time to the reaction-event. In contradiction, an open important question is whether the mean-first-passage-time alone is a sufficient measure for biochemical reactions that involve nanomolar reactant concentrations. Here, using a simple yet generic, exactly solvable model we study the effect of diffusion and chemical reaction-limitations on the full reaction-time distribution. We show that it has a complex structure with four distinct regimes delineated by three characteristic time scales spanning a window of several decades. Consequently, the reaction-times are defocused: no unique time-scale characterises the reaction-process, diffusion- and kinetic-control can no longer be disentangled, and it is imperative to know the full reaction-time distribution. We introduce the concepts of geometry- and reaction-control, and also quantify each regime by calculating the corresponding reaction depth.
Y1 - 2018
UR - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/42299
SN - 2399-3669
VL - 1
PB - Macmillan Publishers Limited
CY - London
ER -