TY  - JOUR
A1  - Send, Tabea Sarah
A1  - Gilles, Maria
A1  - Codd, Veryan
A1  - Wolf, Isabell
A1  - Bardtke, Svenja
A1  - Streit, Fabian
A1  - Strohmaier, Jana
A1  - Frank, Josef
A1  - Schendel, Darja
A1  - Suetterlin, Mark W.
A1  - Denniff, Matthew
A1  - Laucht, Manfred
A1  - Samani, Nilesh J.
A1  - Deuschle, Michael
A1  - Rietschel, Marcella
A1  - Witt, Stephanie H.
T1  - Telomere Length in Newborns is Related to Maternal Stress During Pregnancy
T2  - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
N2  - Telomere length (TL) is a marker of biological aging, and numerous studies have shown associations between TL and somatic or psychiatric disorders. Research also indicates an association between maternal stress during pregnancy and TL in the offspring. The present study investigated possible associations between TL and: (1) maternal perceived stress during pregnancy; (2) a maternal lifetime history of psychiatric disorder (lifetime PD); and (3) paternal age. TL was analyzed in 319 newborns and 318 mothers from a predominantly Caucasian sample (n= 273 Caucasian newborns and n= 274 Caucasian mothers). Two key findings were observed. First, maternal perceived stress during pregnancy was associated with shorter telomeres in newborns but not with maternal TL. Second, maternal lifetime PD was associated with shorter maternal telomeres, but not with TL in newborns. Paternal age was not associated with TL in newborns. The finding that maternal stress during pregnancy is associated with shorter telomeres in newborns supports the results of smaller previous studies. The fact that a relation between maternal prenatal stress and TL was observed in the offspring but not in mothers may be attributable to a high vulnerability to stress during intrauterine development of a maturing organism. To our knowledge, this is the largest study to date to show that maternal stress during pregnancy but not maternal lifetime PD is associated with shorter telomeres in the offspring.
Y1  - 2017
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/46231
SN  - 0893-133X
SN  - 1740-634X
VL  - 42
SP  - 2407
EP  - 2413
PB  - Nature Publ. Group
CY  - London
ER  -