TY  - JOUR
A1  - Nguyen, Hung M.
A1  - Schippers, Jos H. M.
A1  - Goni-Ramos, Oscar
A1  - Christoph, Mathias P.
A1  - Dortay, Hakan
A1  - van der Hoorn, Renier A. L.
A1  - Müller-Röber, Bernd
T1  - An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana
T2  - The plant journal
N2  - In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor Regulator of Proteasomal Gene Expression' (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis-element recognized by RPX is evolutionarily conserved between higher plant species. Upon over-expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.
KW  - Arabidopsis thaliana
KW  - organ size
KW  - evolution
KW  - leaf development
KW  - proteasome
KW  - gene regulatory network
Y1  - 2013
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/35128
SN  - 0960-7412
VL  - 74
IS  - 1
SP  - 25
EP  - 36
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -