TY  - JOUR
A1  - Zhou, Shuo
A1  - Xu, Xun
A1  - Ma, Nan
A1  - Jung, Friedrich
A1  - Lendlein, Andreas
T1  - Influence of sterilization conditions on sulfate-functionalized polyGGE
T2  - Clinical hemorheology and microcirculation : blood flow and vessels
N2  - Sulfated biomolecules are known to influence numerous biological processes in all living organisms. Particularly, they contribute to prevent and inhibit the hypercoagulation condition. The failure of polymeric implants and blood contacting devices is often related to hypercoagulation and microbial contamination. Here, bioactive sulfated biomacromolecules are mimicked by sulfation of poly(glycerol glycidyl ether) (polyGGE) films. Autoclaving, gamma-ray irradiation and ethylene oxide (EtO) gas sterilization techniques were applied to functionalized materials. The sulfate group density and hydrophilicity of sulfated polymers were decreased while chain mobility and thermal degradation were enhanced post autoclaving when compared to those after EtO sterilization. These results suggest that a quality control after sterilization is mandatory to ensure the amount and functionality of functionalized groups are retained.
KW  - Sulfated polymer
KW  - sulfation
KW  - sterilization
KW  - ethylene oxide
Y1  - 2021
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/63842
SN  - 1386-0291
SN  - 1875-8622
VL  - 79
IS  - 4
SP  - 597
EP  - 608
PB  - IOS Press
CY  - Amsterdam
ER  -