TY  - JOUR
A1  - Fujikura, Ushio
A1  - Jing, Runchun
A1  - Hanada, Atsushi
A1  - Takebayashi, Yumiko
A1  - Sakakibara, Hitoshi
A1  - Yamaguchi, Shinjiro
A1  - Kappel, Christian
A1  - Lenhard, Michael
T1  - Variation in splicing efficiency underlies morphological evolution in capsella
T2  - Developmental cell
N2  - Understanding the molecular basis of morphological change remains a central challenge in evolutionary-developmental biology. The transition from outbreeding to selfing is often associated with a dramatic reduction in reproductive structures and functions, such as the loss of attractive pheromones in hermaphroditic Caenorhabditis elegans and a reduced flower size in plants. Here, we demonstrate that variation in the level of the brassinosteroid-biosynthesis enzyme CYP724A1 contributes to the reduced flower size of selfing Capsella rubella compared with its outbreeding ancestor Capsella grandiflora. The primary transcript of the C. rubella allele is spliced more efficiently than that of C. grandiflora, resulting in higher brassinosteroid levels. These restrict organ growth by limiting cell proliferation. More efficient splicing of the C. rubella allele results from two de novo mutations in the selfing lineage. Thus, our results highlight the potentially widespread importance of differential splicing efficiency and higher-than-optimal hormone levels in generating phenotypic variation.
Y1  - 2017
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/53854
SN  - 1534-5807
SN  - 1878-1551
VL  - 44
IS  - 2
SP  - 192
EP  - 203
PB  - Cell Press
CY  - Cambridge
ER  -