TY  - JOUR
A1  - Zaikin, Alexey
A1  - Kurths, Jürgen
T1  - Optimal length transportation hypothesis to model proteasome product size distribution
T2  - Journal of biological physics : emphasizing physical principles in biological research ; an international journal for the formulation and application of mathematical models in the biological sciences
N2  - This paper discusses translocation features of the 20S proteasome in order to explain typical proteasome length distributions. We assume that the protein transport depends significantly on the fragment length with some optimal length which is transported most efficiently. By means of a simple one-channel model, we show that this hypothesis can explain both the one- and the three-peak length distributions found in experiments. A possible mechanism of such translocation is provided by so-called fluctuation-driven transport.
KW  - proteasome
KW  - protein translocation
KW  - stochastic process
KW  - ratchets
Y1  - 2006
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/46897
SN  - 0092-0606
VL  - 32
IS  - 3-4
SP  - 231
EP  - 243
PB  - Springer
CY  - Dordrecht
ER  -