TY  - JOUR
A1  - Sicard, Adrien
A1  - Kappel, Christian
A1  - Josephs, Emily B.
A1  - Wha Lee, Young
A1  - Marona, Cindy
A1  - Stinchcombe, John R.
A1  - Wright, Stephen I.
A1  - Lenhard, Michael
T1  - Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella
T2  - Nature Communications
N2  - In the Bateson–Dobzhansky–Muller model of genetic incompatibilities post-zygotic gene-flow
barriers arise by fixation of novel alleles at interacting loci in separated populations. Many such incompatibilities are polymorphic in plants, implying an important role for genetic drift or balancing selection in their origin and evolution. Here we show that NPR1 and RPP5 loci cause a genetic incompatibility between the incipient species Capsella grandiflora and C. rubella, and the more distantly related C. rubella and C. orientalis. The incompatible RPP5 allele results from a mutation in C. rubella, while the incompatible NPR1 allele is frequent in the ancestral C. grandiflora. Compatible and incompatible NPR1 haplotypes are maintained by balancing selection in C. grandiflora, and were divergently sorted into the derived C. rubella and
C. orientalis. Thus, by maintaining differentiated alleles at high frequencies, balancing selection
on ancestral polymorphisms can facilitate establishing gene-flow barriers between derived populations through lineage sorting of the alternative alleles.
Y1  - 2015
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/9355
SN  - 2041-1723
VL  - 6
PB  - Nature Publishing Group
CY  - London
ER  -