TY  - JOUR
A1  - Trost, Gerda
A1  - Vi, Son Lang
A1  - Czesnick, Hjördis
A1  - Lange, Peggy
A1  - Holton, Nick
A1  - Giavalisco, Patrick
A1  - Zipfel, Cyril
A1  - Kappel, Christian
A1  - Lenhard, Michael
T1  - Arabidopsis poly(A) polymerase PAPS1 limits founder-cell recruitment to organ primordia and suppresses the salicylic acid-independent immune response downstream of EDS1/PAD4
T2  - The plant journal
N2  - Polyadenylation of pre-mRNAs by poly(A) polymerase (PAPS) is a critical process in eukaryotic gene expression. As found in vertebrates, plant genomes encode several isoforms of canonical nuclear PAPS enzymes. In Arabidopsis thaliana these isoforms are functionally specialized, with PAPS1 affecting both organ growth and immune response, at least in part by the preferential polyadenylation of subsets of pre-mRNAs. Here, we demonstrate that the opposite effects of PAPS1 on leaf and flower growth reflect the different identities of these organs, and identify a role for PAPS1 in the elusive connection between organ identity and growth patterns. The overgrowth of paps1 mutant petals is due to increased recruitment of founder cells into early organ primordia, and suggests that PAPS1 activity plays unique roles in influencing organ growth. By contrast, the leaf phenotype of paps1 mutants is dominated by a constitutive immune response that leads to increased resistance to the biotrophic oomycete Hyaloperonospora arabidopsidis and reflects activation of the salicylic acid-independent signalling pathway downstream of ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)/PHYTOALEXIN DEFICIENT4 (PAD4). These findings provide an insight into the developmental and physiological basis of the functional specialization amongst plant PAPS isoforms.
KW  - poly(A) polymerase
KW  - founder-cell recruitment
KW  - organ growth
KW  - polyadenylation
Y1  - 2014
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/38026
SN  - 0960-7412
SN  - 1365-313X
VL  - 77
IS  - 5
SP  - 688
EP  - 699
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -