TY  - JOUR
A1  - Dorenkamp, Marc
A1  - Boldt, Julia
A1  - Leber, Alexander W.
A1  - Sohns, Christian
A1  - Roser, Mattias
A1  - Boldt, Leif-Hendrik
A1  - Haverkamp, Wilhelm
A1  - Bonaventura, Klaus
T1  - Cost-effectiveness of paclitaxel-coated balloon angioplasty in patients with drug-eluting stent restenosis
T2  - Clinical cardiology : international journal for cardiovascular diseases
N2  - BackgroundThe economic impact of drug-eluting stent (DES) in-stent restenosis (ISR) is substantial, highlighting the need for cost-effective treatment strategies.
 HypothesisCompared to plain old balloon angioplasty (POBA) or repeat DES implantation, drug-coated balloon (DCB) angioplasty is a cost-effective therapy for DES-ISR.
 MethodsA Markov state-transition model was used to compare DCB angioplasty with POBA and repeat DES implantation. Model input parameters were obtained from the literature, and the cost analysis was conducted from a German healthcare payer's perspective. Extensive sensitivity analyses were performed.
 ResultsInitial procedure costs amounted to Euro3488 for DCB angioplasty and to Euro2782 for POBA. Over a 6-month time horizon, the DCB strategy was less costly (Euro4028 vs Euro4169) and more effective in terms of life-years (LYs) gained (0.497 versus 0.489) than POBA. The DES strategy incurred initial costs of Euro3167 and resulted in 0.494 LYs gained, at total costs of Euro4101 after a 6-month follow-up. Thus, DCB angioplasty was the least costly and most effective strategy. Base-case results were influenced mostly by initial procedure costs, target lesion revascularization rates, and the costs of dual antiplatelet therapy.
 ConclusionsDCB angioplasty is a cost-effective treatment option for coronary DES-ISR. The higher initial costs of the DCB strategy compared to POBA or repeat DES implantation are offset by later cost savings.
Y1  - 2013
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/34878
SN  - 0160-9289
SN  - 1932-8737
VL  - 36
IS  - 7
SP  - 407
EP  - 413
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -