TY  - JOUR
A1  - Eichelmann, Fabian
A1  - Schulze, Matthias Bernd
A1  - Wittenbecher, Clemens
A1  - Menzel, Juliane
A1  - Weikert, Cornelia
A1  - di Giuseppe, Romina
A1  - Biemann, Ronald
A1  - Isermann, Berend
A1  - Fritsche, Andreas
A1  - Boeing, Heiner
A1  - Aleksandrova, Krasimira
T1  - Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer
T2  - JAMA network open
N2  - IMPORTANCE Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. OBJECTIVE To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. DESIGN, SETTING, AND PARTICIPANTS Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. MAIN OUTCOMES AND MEASURES Incident CRC, colon cancer, and rectal cancer. Baseline chemerin plasma concentrations were measured by enzyme-linked immunosorbent assay. CONCLUSIONS AND RELEVANCE This study found that the association between chemerin concentration and the risk of incident CRC was linear and independent of established CRC risk factors. Further studies are warranted to evaluate chemerin as a novel immune-inflammatory agent in colorectal carcinogenesis.
Y1  - 2019
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/50001
SN  - 2574-3805
VL  - 2
IS  - 3
PB  - American Veterinary Medical Association
CY  - Chicago
ER  -