TY  - GEN
A1  - Mai, Tobias
A1  - Boye, Susanne
A1  - Yuan, Jiayin
A1  - Völkel, Antje
A1  - Gräwert, Marlies
A1  - Günter, Christina
A1  - Lederer, Albena
A1  - Taubert, Andreas
T1  - Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization
N2  - The present article is among the first reports on the effects of poly(ampholyte)s and poly(betaine)s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(trimethylammonium)ethyl methacrylate chloride, 2-((3-cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-sulfopropyl methacrylate potassium salt, and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All the polymers have very high molecular weights of over 106 g mol−1. All polymers are water-soluble and show a strong effect on the precipitation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal Mn = 100 000 g mol−1). Surprisingly, the data show that there is a need for positive charges in the polymers to exert tight control over mineralization and dissolution, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 208 
Y1  - 2015
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/8529
UR  - https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-85299
ER  -