TY  - JOUR
A1  - Amselem, Gabriel
A1  - Theves, Matthias
A1  - Bae, Albert J.
A1  - Beta, Carsten
A1  - Bodenschatz, Eberhard
T1  - Control parameter description of eukaryotic chemotaxis
T2  - Physical review letters
N2  - The chemotaxis of eukaryotic cells depends both on the average concentration of the chemoattractant and on the steepness of its gradient. For the social amoeba Dictyostelium discoideum, we test quantitatively the prediction by Ueda and Shibata [Biophys. J. 93, 11 (2007)] that the efficacy of chemotaxis depends on a single control parameter only, namely, the signal-to-noise ratio (SNR), determined by the stochastic fluctuations of (i) the binding of the chemoattractant molecule to the transmembrane receptor and (ii) the intracellular activation of the effector of the signaling cascade. For SNR less than or similar to 1, the theory captures the experimental findings well, while for larger SNR noise sources further downstream in the signaling pathway need to be taken into account.
Y1  - 2012
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/35653
SN  - 0031-9007
VL  - 109
IS  - 10
PB  - American Physical Society
CY  - College Park
ER  -