TY  - JOUR
A1  - Qiu, Liang
A1  - Zhang, Haoran
A1  - Bick, Thomas
A1  - Martin, Johannes
A1  - Wendler, Petra
A1  - Böker, Alexander
A1  - Glebe, Ulrich
A1  - Xing, Chengfen
T1  - Construction of highly ordered glyco-inside nano-assemblies through RAFT dispersion polymerization of galactose-decorated monomer
T2  - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
N2  - Glyco-assemblies derived from amphiphilic sugar-decorated block copolymers (ASBCs) have emerged prominently due to their wide application, for example, in biomedicine and as drug carriers. However, to efficiently construct these glyco-assemblies is still a challenge. Herein, we report an efficient technology for the synthesis of glyco-inside nano-assemblies by utilizing RAFT polymerization of a galactose-decorated methacrylate for polymerization-induced self-assembly (PISA). Using this approach, a series of highly ordered glyco-inside nano-assemblies containing intermediate morphologies were fabricated by adjusting the length of the hydrophobic glycoblock and the polymerization solids content. A specific morphology of complex vesicles was captured during the PISA process and the formation mechanism is explained by the morphology of its precursor and intermediate. Thus, this method establishes a powerful route to fabricate glyco-assemblies with tunable morphologies and variable sizes, which is significant to enable the large-scale fabrication and wide application of glyco-assemblies.
KW  - galactose-decorated monomer
KW  - glyco-inside nano-assemblies
KW  - morphology
KW  - evolution
KW  - PISA
KW  - RAFT dispersion polymerization
Y1  - 2021
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/62206
SN  - 1433-7851
SN  - 1521-3773
VL  - 60
IS  - 20
SP  - 11098
EP  - 11103
PB  - Wiley-VCH
CY  - Weinheim
ER  -