TY  - JOUR
A1  - Schmidt, Bernd
A1  - Krehl, Stefan
A1  - Kelling, Alexandra
A1  - Schilde, Uwe
T1  - Synthesis of 8-Aryl-Substituted Coumarins based on Ring-Closing Metathesis and Suzuki-Miyaura coupling - synthesis of a Furyl Coumarin natural product from Galipea panamensis
T2  - The journal of organic chemistry
N2  - The synthesis of 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, a natural product with antileishmanial activity recently isolated from the plant Galipea panamensis, is described. The key step is a Suzuki-Miyaura coupling of a furan-3-boronic acid and an 8-halocoumarin, which is advantageously synthesized using a ring-closing metathesis reaction. Several non-natural analogues are also available along these lines.
Y1  - 2012
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/36046
SN  - 0022-3263
VL  - 77
IS  - 5
SP  - 2360
EP  - 2367
PB  - American Chemical Society
CY  - Washington
ER  -