TY  - JOUR
A1  - Fettke, Anja
A1  - Kramer, Markus
A1  - Kleinpeter, Erich
T1  - Lectin-bound conformations and non-covalent interactions of glycomimetic analogs of thiochitobiose
N2  - The bound conformations of five S-glycoside analogs of N,N'-diacetylchitobiose as well as their non- covalent interactions with two lectins, Phytolacca americana lectin (PAL) and wheat germ agglutinin (WGA), are reported. The conformations of the ligands were examined by trNOESY experiments and compared with the free, solution-state conformations and molecular modeling data obtained by force field calculations. In the case of S-aryl, S-glycosides with exclusively S-glycosidic linkages, similar free and lectin-bound conformations and non-covalent interactions were found, whereas they differed for mixed glycosides and for a thiazoline derivative. In addition, STD (saturation transfer difference) NMR magnetization transfer efficiencies at three different temperatures were determined and assessed with respect to the structural differences of these pseudosaccharides. The binding epitopes of each substrate with PAL and WGA were also determined.
Y1  - 2010
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/32155
UR  - http://www.sciencedirect.com/science/journal/00404020
SN  - 0040-4020
ER  -