TY  - JOUR
A1  - Geirhos, Agnes
A1  - Domhardt, Matthias
A1  - Lunkenheimer, Frederike
A1  - Temming, Svenja
A1  - Holl, Reinhard
A1  - Minden, Kirsten
A1  - Warschburger, Petra
A1  - Meissner, Thomas
A1  - Mueller-Stierlin, Annabel S.
A1  - Baumeister, Harald
T1  - Feasibility and potential efficacy of a guided internet- and mobile-based CBT for adolescents and young adults with chronic medical conditions and comorbid depression or anxiety symptoms (youthCOACH(CD)): a randomized controlled pilot trial
T2  - BMC pediatrics
N2  - Background: Adolescents and young adults (AYA) with a chronic medical condition show an increased risk for developing mental comorbidities compared to their healthy peers. Internet- and mobile-based cognitive behavioral therapy (iCBT) might be a low-threshold treatment to support affected AYA. In this randomized controlled pilot trial, the feasibility and potential efficacy of youthCOACH(CD), an iCBT targeting symptoms of anxiety and depression in AYA with chronic medical conditions, was evaluated. Methods: A total of 30 AYA (M-age 16.13; SD= 2.34; 73% female), aged 12-21 years either suffering from cystic fibrosis, juvenile idiopathic arthritis or type 1 diabetes, were randomly assigned to either a guided version of the iCBT youthCOACH(CD) (IC, n=15) or to a waitlist control group (CG, n=15), receiving an unguided version of the iCBT six months post-randomization. Participants of the IG and the CG were assessed before (t0), twelve weeks after (t1) and six months after (t2) randomization. Primary outcome was the feasibility of the iCBT. Different parameters of feasibility e.g. acceptance, client satisfaction or potential side effects were evaluated. First indications of the possible efficacy with regard to the primary efficacy outcome, the Patient Health Questionnaire Anxiety and Depression Scale, and further outcome variables were evaluated using linear regression models, adjusting for baseline values. Results: Regarding feasibility, intervention completion was 60%; intervention satisfaction (M = 25.42, SD = 5.85) and perceived therapeutic alliance (M = 2.83, SD = 1.25) were moderate and comparable to other iCBTs. No patterns emerged regarding subjective and objective negative side effects due to participation in youthCOACH(CD). Estimates of potential efficacy showed between group differences, with a potential medium-term benefit of youthCOACH(CD) (beta = -0.55, 95%Cl: -1.17; 0.07), but probably not short-term (beta = 0.20, 95%Cl: -0.47; 0.88). Conclusions: Our results point to the feasibility of youthCOACH(CD) and the implementation of a future definitive randomized controlled trial addressing its effectiveness and cost-effectiveness. Due to the small sample size, conclusions are premature, however, further strategies to foster treatment adherence should be considered.
KW  - Chronic medical condition
KW  - Depression
KW  - Anxiety
KW  - Internet- and mobile
KW  - based intervention
KW  - Cognitive behavioral therapy
KW  - Randomized controlled
KW  - pilot trial
KW  - Type 1 diabetes
KW  - Cystic fibrosis
KW  - Juvenile idiopathic
KW  - arthritis
Y1  - 2022
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/64117
SN  - 1471-2431
VL  - 22
IS  - 1
PB  - Springer Nature
CY  - London
ER  -