TY  - JOUR
A1  - Schmidt, Bernd
A1  - Elizarov, Nelli
A1  - Schilde, Uwe
A1  - Kelling, Alexandra
T1  - Dual Role of Acetanilides: Traceless Removal of a Directing Group through Deacetylation/Diazotation and Palladium-Catalyzed C-C-Coupling Reactions
T2  - The journal of organic chemistry
N2  - The acetamide group enables regioselective oxidative ortho-C-H activation reactions, such as Pd-catalyzed acylation. The synthetic utility of these transformations can be significantly enhanced by using the acetamide as a quasi-leaving group in a subsequent conventional Pd-catalyzed coupling or cross-coupling reaction. The concept is illustrated herein for the synthesis of o-alkenyl- and o-arylphenones, which have potential for the synthesis of arylated aromatic heterocycles.
Y1  - 2015
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/38957
SN  - 0022-3263
VL  - 80
IS  - 9
SP  - 4223
EP  - 4234
PB  - American Chemical Society
CY  - Washington
ER  -