TY  - JOUR
A1  - Schürmann, Robin Mathis
A1  - Vogel, Stefanie
A1  - Ebel, Kenny
A1  - Bald, Ilko
T1  - The physico-chemical basis of DNA radiosensitization
T2  - Chemistry - a European journal
N2  - High-energy radiation is used in combination with radiosensitizing therapeutics to treat cancer. The most common radiosensitizers are halogenated nucleosides and cisplatin derivatives, and recently also metal nanoparticles have been suggested as potential radiosensitizing agents. The radiosensitizing action of these compounds can at least partly be ascribed to an enhanced reactivity towards secondary low-energy electrons generated along the radiation track of the high-energy primary radiation, or to an additional emission of secondary reactive electrons close to the tumor tissue. This is referred to as physico-chemical radiosensitization. In this Concept article we present current experimental methods used to study fundamental processes of physico-chemical radiosensitization and discuss the most relevant classes of radiosensitizers. Open questions in the current discussions are identified and future directions outlined, which can lead to optimized treatment protocols or even novel therapeutic concepts.
KW  - cancer
KW  - dissociative electron attachment
KW  - low-energy electrons
KW  - radiation therapy
KW  - radiosensitizers
Y1  - 2018
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/52443
SN  - 0947-6539
SN  - 1521-3765
VL  - 24
IS  - 41
SP  - 10271
EP  - 10279
PB  - Wiley-VCH
CY  - Weinheim
ER  -