TY  - JOUR
A1  - Xiong, Chan
A1  - Stiboller, Michael
A1  - Glabonjat, Ronald A.
A1  - Rieger, Jaqueline
A1  - Paton, Lhiam
A1  - Francesconi, Kevin A.
T1  - Transport of arsenolipids to the milk of a nursing mother after consuming salmon fish
T2  - Journal of trace elements in medicine and biology
N2  - Objective: 
We address two questions relevant to infants' exposure to potentially toxic arsenolipids, namely, are the arsenolipids naturally present in fish transported intact to a mother's milk, and what is the efficiency of this transport.

Methods: 
We investigated the transport of arsenolipids and other arsenic species present in fish to mother's milk by analyzing the milk of a single nursing mother at 15 sampling times over a 3-day period after she had consumed a meal of salmon. Total arsenic values were obtained by elemental mass spectrometry, and arsenic species were measured by HPLC coupled to both elemental and molecular mass spectrometry.

Results: 
Total arsenic increased from background levels (0.1 mu g As kg(-1)) to a peak value of 1.72 lig As kg(-1) eight hours after the fish meal. The pattern for arsenolipids was similar to that of total arsenic, increasing from undetectable background levels (< 0.01 mu g As kg(-1)) to a peak after eight hours of 0.45 mu g As kg(-1). Most of the remaining total arsenic in the milk was accounted for by arsenobetaine. The major arsenolipids in the salmon were arsenic hydrocarbons (AsHCs; 55 % of total arsenolipids), and these compounds were also the dominant arsenolipids in the milk where they contributed over 90 % of the total arsenolipids. 

Conclusions:
Our study has shown that ca 2-3 % of arsenic hydrocarbons, natural constituents of fish, can be directly transferred unchanged to the milk of a nursing mother. In view of the potential neurotoxicity of AsHCs, the effects of these compounds on the brain developmental stage of infants need to be investigated.
KW  - human milk
KW  - arsenolipids
KW  - salmon fish
KW  - HPLC/ICPMS
KW  - HPLC/HR-ESMS
Y1  - 2020
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/60120
SN  - 0946-672X
VL  - 61
PB  - Elsevier
CY  - München
ER  -