TY  - JOUR
A1  - Chen, Ye
A1  - Song, Qilei
A1  - Zhao, Junpeng
A1  - Gong, Xiangjun
A1  - Schlaad, Helmut
A1  - Zhang, Guangzhao
T1  - Betulin-Constituted multiblock amphiphiles for broad-spectrum protein resistance
T2  - ACS applied materials & interfaces
N2  - Multiblock-like amphiphilic polyurethanes constituted by poly(ethylene oxide) and biosourced betulin are designed for antifouling and synthesized by a convenient organocatalytic route comprising tandem chain-growth and step-growth polymerizations. The doping density of betulin (D-B) in the polymer chain structure is readily varied by a mixed-initiator strategy. The spin-coated polymer films exhibit unique nanophase separation and protein resistance behaviors. Higher D-B leads to enhanced surface hydrophobicity and, unexpectedly, improved protein resistance. It is found that the surface holds molecular-level heterogeneity when D-B is substantially high due to restricted phase separation; therefore, broad-spectrum protein resistance is achieved despite considerable surface hydrophobicity. As D-B decreases, the distance between adjacent betulin units increases so that hydrophobic nanodomains are formed, which provide enough landing areas for relatively small-sized proteins to adsorb on the surface.
KW  - amphiphilic surface
KW  - antifouling
KW  - multiblock copolymer
KW  - organocatalytic polymerization
KW  - renewable resource
Y1  - 2018
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/53512
SN  - 1944-8244
VL  - 10
IS  - 7
SP  - 6593
EP  - 6600
PB  - American Chemical Society
CY  - Washington
ER  -