TY  - JOUR
A1  - Schmicker, Marlen
A1  - Frühling, Insa
A1  - Menze, Inga
A1  - Glanz, Wenzel
A1  - Müller, Patrick
A1  - Noesselt, Toemme
A1  - Müller, Notger Germar
T1  - The potential role of gustatory function as an early diagnostic marker for the risk of alzheimer's disease in subjective cognitive decline
T2  - Journal of Alzheimer's disease reports : JADR
N2  - Background: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer's disease (AD) although psychophysical testing does not reveal any cognitive deficit. 

Objective: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. 

Methods: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD-) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin' Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. 

Results: Only taste was able to distinguish between HC/SCD- and SCD+ patients.

Conclusion: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition.
KW  - Alzheimer's disease
KW  - dementia
KW  - diagnostic marker
KW  - early diagnosis
KW  - subjective cognitive decline
KW  - taste
Y1  - 2023
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/64398
SN  - 2542-4823
VL  - 7
IS  - 1
SP  - 249
EP  - 262
PB  - IOS Press
CY  - Clifton, VA
ER  -