TY  - JOUR
A1  - Reimann, Anna
A1  - Beyer, Rudolf
A1  - Mumm, Rebekka
A1  - Scheffler, Christiane
T1  - Reference tables with centiles of limb to body height ratios of healthy human adults for assessing potential thalidomide embryopathy
T2  - Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft für Anthropologie
N2  - Background: Over 60 years ago the biggest drug catastrophe in Germany took place. The drug thalidomide, sold by the German pharmaceutical company Chemie Grunenthal GmbH starting in 1957 under the name "Contergan", caused severe birth defects in newborns. Chemie Grunenthal withdraw Contergan in 1961. Until nearly 30 years later in 1988 there were already over 10.000 children born with severe birth defects (e.g. dysmelia, amelia, congenital heart defect). Due to the high variability of the birth defects caused by thalidomide, later called thalidomide embryopathy, there is still no detailed information about the proportions of limbs. Aim: The aim is to develop reference centiles for limb measurements of men and women aged 19-70 years old. Method: For the calculation, data of healthy men and women (m = 2984, f = 2838) from former East Germany were used and centiles using the LMS-method were developed. Results: Centile tables for arm and leg length of men and women are presented in the results. The variability is small due to a homogeneous distribution of the measurements. A test with randomly chosen patient data shows that women under 171 cm stature and men under 180 cm stature can be assessed correctly. A severe shortening of limbs can be detected with this method.
KW  - thalidomide embryopathy
KW  - contergan
KW  - anthropometry
KW  - body proportions
Y1  - 2019
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/50552
SN  - 0003-5548
VL  - 76
IS  - 5
SP  - 391
EP  - 400
PB  - Schweizerbart
CY  - Stuttgart
ER  -