TY  - JOUR
A1  - Nishino, Takeshi
A1  - Okamoto, Ken
A1  - Leimkühler, Silke
T1  - Enzymes of the Xanthine Oxidase Family
T2  - Molybdenum and tungsten enzymes : biochemistry
N2  - Enzymes from the xanthine oxidase (XO) family of molybdenum enzymes are generally, with some exceptions, molybdenum iron–sulfur flavin hydroxylases. Mammalian xanthine oxidoreductase and aldehyde oxidase were among the first enzymes to be studied in detail more than 100 years ago and, surprisingly, they continue to be thoroughly studied in molecular detail with many open and unresolved questions remaining. Enzymes of the XO family are characterized by a molybdenum cofactor (Moco) active site with a MoVIOS(OH) ligand sphere where substrate hydroxylation of either aromatic or aliphatic carbon centers is catalyzed. During the reaction, electrons are transferred to the oxidizing substrate, most commonly O2 or NAD+, which react at the FAD site.
Y1  - 2016
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/56213
SN  - 978-1-78262-391-5
SN  - 978-1-78262-089-1
SN  - 978-1-78262-881-1
VL  - 5
SP  - 192
EP  - 239
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -