TY  - JOUR
A1  - Nordmeyer, Sarah
A1  - Kraus, Milena
A1  - Ziehm, Matthias
A1  - Kirchner, Marieluise
A1  - Schafstedde, Marie
A1  - Kelm, Marcus
A1  - Niquet, Sylvia
A1  - Stephen, Mariet Mathew
A1  - Baczko, Istvan
A1  - Knosalla, Christoph
A1  - Schapranow, Matthieu-Patrick
A1  - Dittmar, Gunnar
A1  - Gotthardt, Michael
A1  - Falcke, Martin
A1  - Regitz-Zagrosek, Vera
A1  - Kuehne, Titus
A1  - Mertins, Philipp
T1  - Disease- and sex-specific differences in patients with heart valve disease
T2  - Life Science Alliance
N2  - Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group-specific and sex-specific differences have been observed. Male patients with aortic stenosis showed more proteins related to fibrosis and less to energy metabolism, whereas female patients showed strong reduction in proteostasis-related proteins. Clinical imaging was in line with proteomic findings, showing elevation of fibrosis in both patient groups and sex differences. Disease-and sex-specific proteomic profiles provide insight into cardiac remodeling in patients with heart valve disease and might help improve the understanding of molecular mechanisms and the development of individualized treatment strategies.
Y1  - 2023
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/64228
SN  - 2575-1077
VL  - 6
IS  - 3
PB  - EMBO Press
CY  - Heidelberg
ER  -