TY  - JOUR
A1  - Lu, Yong-Ping
A1  - Hasan, Ahmed A.
A1  - Zeng, Shufei
A1  - Hocher, Berthold
T1  - Plasma ET-1 concentrations are elevated in pregnant women with hypertension - meta-analysis of clinical studies
T2  - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft
N2  - Background/Aims:
The ET system might be involved in the pathogenesis of hypertensive disorders during pregnancy. The objective is to analyse the impact of ET-1 in hypertensive pregnant women by a strict meta-analysis of published human clinical studies. 
Methods:
Based on the principle of Cochrane systematic reviews, Cohort studies in PubMed (Medline), Google Scholar and China Biological Medicine Database (CBM-disc) designed to identify the role of endothelin-1 (ET-1) in the pathophysiology of gestational hypertension and preeclampsia were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects model.
Results:
Sixteen published cohort studies including 1739 hypertensive cases and 409 controls were used in the meta-analysis. ET-1 plasma concentrations were higher in hypertensive pregnant women as compared to the controls (mean difference between groups: 19.02 [15.60～22.44], P < 0.00001,). These finding were driven by severity of hypertension and/or degree of proteinuria.
Conclusion:
Plasma ET-1 concentrations are elevated in hypertensive disorders during human pregnancy. In particular women with preeclampsia (hypertensive pregnant women with proteinuria) have substantially elevated plasma ET-1 concentration as compared to pregnant women with normal blood pressure.
KW  - Et-1
KW  - Pregnancy
KW  - Hypertension
KW  - Meta-analysis
Y1  - 2017
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/55589
SN  - 1420-4096
SN  - 1423-0143
VL  - 42
IS  - 4
SP  - 654
EP  - 663
PB  - Karger
CY  - Basel
ER  -