TY  - JOUR
A1  - Rohn, Isabelle
A1  - Raschke, Stefanie
A1  - Aschner, Michael
A1  - Tuck, Simon
A1  - Kuehnelt, Doris
A1  - Kipp, Anna Patricia
A1  - Schwerdtle, Tanja
A1  - Bornhorst, Julia
T1  - Treatment of caenorhabditis elegans with small selenium species enhances antioxidant defense systems
T2  - Molecular nutrition & food research : bioactivity, chemistry, immunology, microbiology, safety, technology
N2  - ScopeSmall selenium (Se) species play a key role in Se metabolism and act as dietary sources of the essential trace element. However, they are redox-active and trigger pro- and antioxidant responses. As health outcomes are strongly species-dependent, species-specific characteristics of Se compounds are tested in vivo. Methods and resultsIn the model organism Caenorhabditis elegans (C. elegans), immediate and sustained effects of selenite, selenomethionine (SeMet), and Se-methylselenocysteine (MeSeCys) are studied regarding their bioavailability, incorporation into proteins, as well as modulation of the cellular redox status. While all tested Se compounds are bioavailable, only SeMet persistently accumulates and is non-specifically incorporated into proteins. However, the protection toward chemically-induced formation of reactive species is independent of the applied Se compound. Increased thioredoxin reductase (TXNRD) activity and changes in mRNA expression levels of antioxidant proteins indicate the activation of cellular defense mechanisms. However, in txnrd-1 deletion mutants, no protective effects of the Se species are observed anymore, which is also reflected by differential gene expression data. ConclusionSe species protect against chemically-induced reactive species formation. The identified immediate and sustained systemic effects of Se species give rise to speculations on possible benefits facing subsequent periods of inadequate Se intake.
KW  - antioxidant defense systems
KW  - caenorhabditis elegans
KW  - selenium
KW  - oxidative stress
KW  - selenoproteins
Y1  - 2019
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/49497
SN  - 1613-4125
SN  - 1613-4133
VL  - 63
IS  - 9
PB  - Wiley
CY  - Hoboken
ER  -