TY  - JOUR
A1  - Schenk, Matthew
A1  - Eichelmann, Fabian
A1  - Schulze, Matthias Bernd
A1  - Rudovich, Natalia
A1  - Pfeiffer, Andreas F. H.
A1  - di Giuseppe, Romina
A1  - Böing, Heiner
A1  - Aleksandrova, Krasimira
T1  - Reproducibility of novel immune-inflammatory biomarkers over 4 months
T2  - Biomarkers in medicine
N2  - Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-beta, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-beta (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-beta was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.
KW  - clusterin
KW  - immune-inflammatory biomarkers
KW  - MMF
KW  - repeated measures design
KW  - reproducibility
KW  - suPAR
KW  - TGF-beta
Y1  - 2019
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/49095
SN  - 1752-0363
SN  - 1752-0371
VL  - 13
IS  - 8
SP  - 639
EP  - 648
PB  - Future Medicine
CY  - London
ER  -