TY - JOUR A1 - Petrović, Saša A1 - Wendler, Petra T1 - A RADD approach to probing AAA plus protein function T2 - Nature structural & molecular biology N2 - AAA+ proteins (ATPases associated with various cellular activities) catalyze the energy-dependent movement or rearrangement of macromolecules. A new study addresses the important question of how to design a selective chemical inhibitor for specific proteins in this diverse superfamily. The powerful chemical genetics approach adds to a growing toolbox of applications that allow dissection of the functions of distinct AAA+ proteins in vivo, facilitating the first steps toward effective drug development. Y1 - 2021 UR - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/57442 SN - 1545-9993 SN - 1545-9985 VL - 28 IS - 4 SP - 329 EP - 330 PB - Nature Publishing Group CY - Berlin ER -