TY  - JOUR
A1  - Folikumah, Makafui Yao
A1  - Behl, Marc
A1  - Lendlein, Andreas
T1  - Thiol-Thioester exchange reactions in precursors enable pH-triggered hydrogel formation
T2  - Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences
N2  - Bio-interactive hydrogel formation in situ requires sensory capabilities toward physiologically relevant stimuli. Here, we report on pH-controlled in situ hydrogel formation relying on latent cross-linkers, which transform from pH sensors to reactive molecules. In particular, thiopeptolide/thio-depsipeptides were capable of pH-sensitive thiol-thioester exchange reactions to yield a,co-dithiols, which react with maleimide-functionalized multi-arm polyethylene glycol to polymer networks. Their water solubility and diffusibility qualify thiol/thioester-containing peptide mimetics as sensory precursors to drive in situ localized hydrogel formation with potential applications in tissue regeneration such as treatment of inflamed tissues of the urinary tract.
Y1  - 2021
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/61424
SN  - 1525-7797
SN  - 1526-4602
VL  - 22
IS  - 5
SP  - 1875
EP  - 1884
PB  - American Chemical Society
CY  - Washington
ER  -