TY  - JOUR
A1  - Mai, Tobias
A1  - Boye, Susanne
A1  - Yuan, Jiayin
A1  - Voelkel, Antje
A1  - Graewert, Marlies
A1  - Günter, Christina
A1  - Lederer, Albena
A1  - Taubert, Andreas
T1  - Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization
T2  - RSC Advances
N2  - The present article is among the first reports on the effects of poly(ampholyte)s and poly(betaine) s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(trimethylammonium) ethyl methacrylate chloride, 2-((3-cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-sulfopropyl methacrylate potassium salt, and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All the polymers have very high molecular weights of over 10(6) g mol(-1). All polymers are water-soluble and show a strong effect on the precipitation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal M-n = 100 000 g mol(-1)). Surprisingly, the data show that there is a need for positive charges in the polymers to exert tight control over mineralization and dissolution, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.
Y1  - 2015
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/39267
SN  - 2046-2069
VL  - 5
IS  - 125
SP  - 103494
EP  - 103505
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -