TY  - JOUR
A1  - Niehoff, Ann-Christin
A1  - Schulz, Jacqueline
A1  - Soltwisch, Jens
A1  - Meyer, Soren
A1  - Kettling, Hans
A1  - Sperling, Michael
A1  - Jeibmann, Astrid
A1  - Dreisewerd, Klaus
A1  - Francesconi, Kevin A.
A1  - Schwerdtle, Tanja
A1  - Karst, Uwe
T1  - Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster
T2  - Analytical chemistry
N2  - Arsenic-containing lipids (arsenolipids) are natural products of marine organisms such as fish, invertebrates, and algae, many of which are important seafoods. A major group of arsenolipids, namely, the arsenic-containing hydrocarbons (AsHC), have recently been shown to be cytotoxic to human liver and bladder cells, a result that has stimulated interest in the chemistry and toxicology of these compounds. In this study, elemental laser ablation-inductively coupled plasma mass spectrometry (LA-ICPMS) and molecular matrix-assisted laser desorption/ionization (MALDI-)MS were used to image and quantify the uptake of an AsHC in the model organism Drosophila melanogaster. Using these two complementary methods, both an enrichment of arsenic and the presence of the AsHC in the brain were revealed, indicating that the intact arsenolipid had crossed the blood-brain barrier. Simultaneous acquisition of quantitative elemental concentrations and molecular distributions could allow new insight into organ-specific enrichment and possible transportation processes of arsenic-containing bioactive compounds in living organisms.
Y1  - 2016
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/45338
SN  - 0003-2700
SN  - 1520-6882
VL  - 88
SP  - 5258
EP  - 5263
PB  - American Chemical Society
CY  - Washington
ER  -