TY  - JOUR
A1  - Kuhlmann, Stella
A1  - Tschorn, Mira
A1  - Arolt, Volker
A1  - Beer, Katja
A1  - Brandt, Julia
A1  - Grosse, Laura
A1  - Haverkamp, Wilhelm
A1  - Müller-Nordhorn, Jacqueline
A1  - Rieckmann, Nina
A1  - Waltenberger, Johannes
A1  - Warnke, Katharina
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
T1  - Serum brain-derived neurotrophic factor and stability of depressive symptoms in coronary heart disease patients
T2  - Psychoneuroendocrinology : an international journal ; the official journal of the International Society of Psychoneuroendocrinology
N2  - Objective:
Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients.
Methods:
At baseline, N = 225 CHD patients were enrolled while hospitalized. Of these, N = 190 (84%) could be followed up 6 months later. Depressive symptoms were assessed both at baseline and at the 6-months follow-up using the Patient Health Questionnaire (PHQ-9). Serum BDNF concentrations were measured using fluorometric Enzyme-linked immunosorbent assays (ELISA).
Results:
Logistic regression models showed that lower BDNF levels were associated with persistent depressive symptoms, even after adjustment for age, sex, smoking and potential medical confounders. The incidence of depressive symptoms was not related to lower BDNF levels. However, somatic comorbidity (as measured by the Charlson Comorbidity Index) was significantly associated with the incidence of depressive symptoms.
Conclusions:
Our findings suggest a role of BDNF in the link between CHD and depressive symptoms. Particularly, low serum BDNF levels could be considered as a valuable biomarker for the persistence of depressive symptoms among depressed CHD patients.
KW  - Brain-derived neurotrophic factor (BDNF)
KW  - Coronary heart disease (CHD)
KW  - Depression
KW  - Serum
Y1  - 2016
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/55275
SN  - 0306-4530
VL  - 77
SP  - 196
EP  - 202
PB  - Elsevier Science
CY  - Oxford
ER  -