TY  - JOUR
A1  - Reichetzeder, Christoph
A1  - Putra, Sulistyo Emantoko Dwi
A1  - Li, Jian
A1  - Hocher, Berthold
T1  - Developmental Origins of Disease - Crisis Precipitates Change
T2  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - The concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines general underlying mechanisms and particularly discusses mechanistic explanations for sexual dimorphism in developmental programming. Furthermore, novel hypotheses are presented emphasizing a non-mendelian impact of parental genes on the offspring's phenotype.
KW  - Nutrition
KW  - Thrifty phenotype
KW  - Developmental programming
KW  - Paternal, maternal, sex differences
KW  - Epigenetics
Y1  - 2016
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/45754
SN  - 1015-8987
SN  - 1421-9778
VL  - 39
SP  - 919
EP  - 938
PB  - Karger
CY  - Basel
ER  -