TY  - JOUR
A1  - Bender, Stephan
A1  - Banaschewski, Tobias
A1  - Rößner, Veit
A1  - Klein, Christoph
A1  - Rietschel, Marcella
A1  - Feige, Bernd
A1  - Brandeis, Daniel
A1  - Laucht, Manfred
T1  - Variability of single trial brain activation predicts fluctuations in reaction time
T2  - Biological psychology
N2  - Brain activation stability is crucial to understanding attention lapses. EEG methods could provide excellent markers to assess neuronal response variability with respect to temporal (intertrial coherence) and spatial variability (topographic consistency) as well as variations in activation intensity (low frequency variability of single trial global field power).
 We calculated intertrial coherence, topographic consistency and low frequency amplitude variability during target P300 in a continuous performance test in 263 15-year-olds from a cohort with psychosocial and biological risk factors.
 Topographic consistency and low frequency amplitude variability predicted reaction time fluctuations (RTSD) in a linear model. Higher RTSD was only associated with higher psychosocial adversity in the presence of the homozygous 6R-10R dopamine transporter haplotype.
 We propose that topographic variability of single trial P300 reflects noise as well as variability in evoked cortical activation patterns. Dopaminergic neuromodulation interacted with environmental and biological risk factors to predict behavioural reaction time variability. (C) 2015 Elsevier B.V. All rights reserved.
KW  - Event related potential
KW  - Haplotype
KW  - Intertrial coherence
KW  - Topographic consistency
KW  - Low frequency amplitude variability
KW  - Psychosocial stress
Y1  - 2015
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/39114
SN  - 0301-0511
SN  - 1873-6246
VL  - 106
SP  - 50
EP  - 60
PB  - Elsevier
CY  - Amsterdam
ER  -