TY  - JOUR
A1  - Lange, Maik
A1  - Braune, Steffen
A1  - Luetzow, Karola
A1  - Richau, Klaus
A1  - Scharnagl, Nico
A1  - Weinhart, Marie
A1  - Neffe, Axel T.
A1  - Jung, Friedrich
A1  - Haag, Rainer
A1  - Lendlein, Andreas
T1  - Surface functionalization of poly(ether imide) membranes with linear, methylated oligoglycerols for reducing thrombogenicity
JF  - Macromolecular rapid communications
N2  - Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
KW  - hemocompatibility
KW  - poly(ethylene glycol)
KW  - polyglycerol
KW  - polyimides
KW  - surface chemistry
Y1  - 2012
U6  - https://doi.org/10.1002/marc.201200426
SN  - 1022-1336
VL  - 33
IS  - 17
SP  - 1487
EP  - 1492
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Neffe, Axel T.
A1  - von Rüsten-Lange, Maik
A1  - Braune, Steffen
A1  - Lützow, Karola
A1  - Roch, Toralf
A1  - Richau, Klaus
A1  - Jung, Friedrich
A1  - Lendlein, Andreas
T1  - Poly(ethylene glycol) grafting to Poly(ether imide) membranes - influence on protein adsorption and Thrombocyte adhesion
JF  - Macromolecular bioscience
N2  - The chain length and end groups of linear PEG grafted on smooth surfaces is known to influence protein adsorption and thrombocyte adhesion. Here, it is explored whether established structure function relationships can be transferred to application relevant, rough surfaces. Functionalization of poly(ether imide) (PEI) membranes by grafting with monoamino PEG of different chain lengths (M-n=1kDa or 10kDa) and end groups (methoxy or hydroxyl) is proven by spectroscopy, changes of surface hydrophilicity, and surface shielding effects. The surface functionalization does lead to reduction of adsorption of BSA, but not of fibrinogen. The thrombocyte adhesion is increased compared to untreated PEI surfaces. Conclusively, rough instead of smooth polymer or gold surfaces should be investigated as relevant models.
KW  - biomaterials
KW  - poly(ethylene glycol)
KW  - protein adsorption
KW  - surface functionalization
KW  - thrombocyte adhesion
Y1  - 2013
U6  - https://doi.org/10.1002/mabi.201300309
SN  - 1616-5187
SN  - 1616-5195
VL  - 13
IS  - 12
SP  - 1720
EP  - 1729
PB  - Wiley-VCH
CY  - Weinheim
ER  -