TY  - JOUR
A1  - Steinfath, Matthias
A1  - Strehmel, Nadine
A1  - Peters, Rolf
A1  - Schauer, Nicolas
A1  - Groth, Detlef
A1  - Hummel, Jan
A1  - Steup, Martin
A1  - Selbig, Joachim
A1  - Kopka, Joachim
A1  - Geigenberger, Peter
A1  - Dongen, Joost T. van
T1  - Discovering plant metabolic biomarkers for phenotype prediction using an untargeted approach
N2  - Biomarkers are used to predict phenotypical properties before these features become apparent and, therefore, are valuable tools for both fundamental and applied research. Diagnostic biomarkers have been discovered in medicine many decades ago and are now commonly applied. While this is routine in the field of medicine, it is of surprise that in agriculture this approach has never been investigated. Up to now, the prediction of phenotypes in plants was based on growing plants and assaying the organs of interest in a time intensive process. For the first time, we demonstrate in this study the application of metabolomics to predict agronomic important phenotypes of a crop plant that was grown in different environments. Our procedure consists of established techniques to screen untargeted for a large amount of metabolites in parallel, in combination with machine learning methods. By using this combination of metabolomics and biomathematical tools metabolites were identified that can be used as biomarkers to improve the prediction of traits. The predictive metabolites can be selected and used subsequently to develop fast, targeted and low-cost diagnostic biomarker assays that can be implemented in breeding programs or quality assessment analysis. The identified metabolic biomarkers allow for the prediction of crop product quality. Furthermore, marker-assisted selection can benefit from the discovery of metabolic biomarkers when other molecular markers come to its limitation. The described marker selection method was developed for potato tubers, but is generally applicable to any crop and trait as it functions independently of genomic information.
Y1  - 2010
UR  - http://www3.interscience.wiley.com/cgi-bin/issn?DESCRIPTOR=PRINTISSN&VALUE=1467-7644
U6  - https://doi.org/10.1111/j.1467-7652.2010.00516.x
SN  - 1467-7644
ER  - 
TY  - GEN
A1  - Wippert, Pia-Maria
A1  - Block, Andrea
A1  - Mansuy, Isabelle M.
A1  - Peters, Eva M. J.
A1  - Rose, Matthias
A1  - Rapp, Michael Armin
A1  - Huppertz, Alexander
A1  - Würtz-Kozak, Karin
T1  - Alterations in Bone Homeostasis and Microstructure Related to Depression and Allostatic Load
T2  - Psychotherapy and Psychosomatics
Y1  - 2019
U6  - https://doi.org/10.1159/000503640
SN  - 0033-3190
SN  - 1423-0348
VL  - 88
IS  - 6
SP  - 383
EP  - 385
PB  - Karger
CY  - Basel
ER  - 
TY  - GEN
A1  - Kalkuhl, Matthias
A1  - Steckel, Jan Christoph
A1  - Montrone, Lorenzo
A1  - Jakob, Michael
A1  - Peters, Jörg
A1  - Edenhofer, Ottmar
T1  - Successful coal phase-out requires new models of development
T2  - Nature Energy
N2  - Different energy sources have different spillovers on economic development and industrialization. Pathways of economic development based on renewable energy sources might require additional policies to support industrial development.
Y1  - 2019
U6  - https://doi.org/10.1038/s41560-019-0500-5
SN  - 2058-7546
VL  - 4
IS  - 11
SP  - 897
EP  - 900
PB  - Nature Publ. Group
CY  - London
ER  -