TY  - JOUR
A1  - Silanteva, Irina A.
A1  - Komolkin, Andrei
A1  - Mamontova, Veronika V.
A1  - Vorontsov-Velyaminov, Pavel N.
A1  - Santer, Svetlana
A1  - Kasyanenko, Nina A.
T1  - Some features of surfactant organization in DNA solutions at various NaCl concentrations
JF  - ACS omega / American Chemical Society
N2  - The photosensitive azobenzene-containing surfactant C-4-Azo-OC(6)TMAB is a promising agent for reversible DNA packaging in a solution. The simulation of the trans-isomer surfactant organization into associates in a solution with and without salt as well as its binding to DNA at different NaCl concentrations was carried out by molecular dynamics. Experimental data obtained by spectral and hydrodynamic methods were used to verify the results of simulation. It was shown that head-to-tail aggregates with close to antiparallel orientation of surfactant molecules were formed at certain NaCl and surfactant concentrations (below critical micelle concentration). Such aggregates have two positively charged ends, and therefore, they can be attracted to negatively charged DNA phosphates far located along the chain, as well as those that belong to different molecules. This contributes to the formation of intermolecular DNA-DNA contacts, and this way, the experimentally observed precipitation of DNA can be explained.
Y1  - 2020
U6  - https://doi.org/10.1021/acsomega.0c01850
SN  - 2470-1343
VL  - 5
IS  - 29
SP  - 18234
EP  - 18243
PB  - ACS Publications
CY  - Washington
ER  - 
TY  - JOUR
A1  - Silanteva, Irina A.
A1  - Komolkin, Andrei
A1  - Mamontova, Veronika V.
A1  - Gabrusenok, Pavel
A1  - Vorontsov-Velyaminov, Pavel N.
A1  - Santer, Svetlana
A1  - Kasyanenko, Nina A.
T1  - Cis-isomers of photosensitive cationic azobenzene surfactants in DNA solutions at different NaCl concentrations
BT  - Experiment and modeling
JF  - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry
N2  - The DNA interaction with cis-isomers of photosensitive azobenzene-containing surfactants was studied by both experimental methods and computer simulation. It was shown that before the organization of micelles, such surfactants in the cis-conformation form associates of only a single type with a disordered orientation of molecules. In contrast, for trans-isomers, there exist two types of associates with head-to-head or head-to-tail orientations of molecules in dependence on salt concentration in a solution. The comparison of cis- and trans-isomer binding to DNA and the influence of salt concentration on the formation of their complexes with DNA were studied. It was shown that cis-isomers interact with phosphate groups of DNA and that their molecules were also located along the minor groove of DNA.
Y1  - 2021
U6  - https://doi.org/10.1021/acs.jpcb.1c07864
SN  - 1520-6106
SN  - 1520-5207
VL  - 125
IS  - 40
SP  - 11197
EP  - 11207
PB  - American Chemical Society
CY  - Washington
ER  -