@article{BergerToerjekAltmann2004,
  author    = {Berger, Dieter and T{\"o}rjek, Otto and Altmann, Thomas},
  title     = {Establishment of high-efficiency mapping tools},
  isbn      = {3-00-011587-0},
  year      = {2004},
  language  = {en}
}
@article{ScheibleToerjekAltmann2004,
  author    = {Scheible, W. R. and T{\"o}rj{\´e}k, Otto and Altmann, Thomas},
  title     = {From markers to cloned genes : map based cloning},
  isbn      = {3-540-20689-2},
  year      = {2004},
  language  = {en}
}
@article{MeyerToerjekBecheretal.2004,
  author    = {Meyer, Rhonda C. and T{\"o}rj{\´e}k, Otto and Becher, Monika and Altmann, Thomas},
  title     = {Heterosis of biomass production in Arabidopsis : Establishment during early development},
  year      = {2004},
  abstract  = {Heterosis has been widely used in agriculture to increase yield and to broaden adaptability of hybrid varieties and is applied to an increasing number of crop species. We performed a systematic survey of the extent and degree of heterosis for dry biomass in 63 Arabidopsis accessions crossed to three reference lines (Col-0, C24, and Nd). We detected a high heritability (69\%) for biomass production in Arabidopsis. Among the 169 crosses analyzed, 29 exhibited significant mid-parent-heterosis for shoot biomass. Furthermore, we analyzed two divergent accessions, C24 and Col-0, the F-1 hybrids of which were shown to exhibit hybrid vigor, in more detail. In the combination Col-0/C24, heterosis for biomass was enhanced at higher light intensities; we found 51\% to 66\% mid-parent-heterosis at low and intermediate light intensities (60 and 120 mumol m(-2) s(-1)), and 161\% at high light intensity (240 mumol m(-2) s(-1)). While at the low and intermediate light intensities relative growth rates of the hybrids were higher only in the early developmental phase (0-15 d after sowing [DAS]), at high light intensity the hybrids showed increased relative growth rates over the entire vegetative phase (until 25 DAS). An important finding was the early onset of heterosis for biomass; in the cross Col-0/C24, differences between parental and hybrid lines in leaf size and dry shoot mass could be detected as early as 10 DAS. The widespread occurrence of heterosis in the model plant Arabidopsis opens the possibility to investigate the genetic basis of this phenomenon using the tools of genetical genomics},
  language  = {en}
}
@article{AltmannToerjekBergeretal.2003,
  author    = {Altmann, Thomas and T{\"o}rjek, Otto and Berger, Dieter and Meyer, Rhonda C. and M{\"u}ssig, Carsten and Schmidt, K. J. and Sorensen, T. R. and Weisshaar, Bernd and Olds-Mitchell, T.},
  title     = {Establishment of a high-efficiency SNP-based framework marker set for Arabidopsis},
  year      = {2003},
  language  = {en}
}
@article{AltmannSchmidSoerensenetal.2003,
  author    = {Altmann, Thomas and Schmid, K. J. and S{\"o}rensen, Rossleff T. and Stracke, R. and T{\"o}rjek, Otto and Mitchel-Olds, T. and Weisshaar, Bernd},
  title     = {Large-scale identification and analysis of genome-wide single-nucleotide polymorphisms for mapping in Arabidopsis thaliana},
  year      = {2003},
  language  = {en}
}
@article{SchmidTorjekMeyeretal.2006,
  author    = {Schmid, Karl J. and Torjek, Otto and Meyer, Rhonda C. and Schmuths, Heike and Hoffmann, Matthias H. and Altmann, Thomas},
  title     = {Evidence for a large-scale population structure of Arabidopsis thaliana from genome-wide single nucleotide polymorphism markers},
  doi       = {10.1007/s00122-006-0212-7},
  year      = {2006},
  abstract  = {Population-based methods for the genetic mapping of adaptive traits and the analysis of natural selection require that the population structure and demographic history of a species are taken into account. We characterized geographic patterns of genetic variation in the model plant Arabidopsis thaliana by genotyping 115 genome-wide single nucleotide polymorphism (SNP) markers in 351 accessions from the whole species range using a matrix-assisted laser desorption/ionization time-of-flight assay, and by sequencing of nine unlinked short genomic regions in a subset of 64 accessions. The observed frequency distribution of SNPs is not consistent with a constant-size neutral model of sequence polymorphism due to an excess of rare polymorphisms. There is evidence for a significant population structure as indicated by differences in genetic diversity between geographic regions. Accessions from Central Asia have a low level of polymorphism and an increased level of genome-wide linkage disequilibrium (LD) relative to accessions from the Iberian Peninsula and Central Europe. Cluster analysis with the structure program grouped Eurasian accessions into K=6 clusters. Accessions from the Iberian Peninsula and from Central Asia constitute distinct populations, whereas Central and Eastern European accessions represent admixed populations in which genomes were reshuffled by historical recombination events. These patterns likely result from a rapid postglacial recolonization of Eurasia from glacial refugial populations. Our analyses suggest that mapping populations for association or LD mapping should be chosen from regional rather than a species-wide sample or identified genetically as sets of individuals with similar average genetic distances},
  language  = {en}
}
@article{BurkartWacoJosefssonDilkesetal.2012,
  author    = {Burkart-Waco, Diana and Josefsson, Caroline and Dilkes, Brian and Kozloff, Nora and Torjek, Otto and Meyer, Rhonda C. and Altmann, Thomas and Comai, Luca},
  title     = {Hybrid incompatibility in arabidopsis is determined by a Multiple-Locus genetic network},
  series = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
  volume    = {158},
  journal   = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
  number    = {2},
  publisher = {American Society of Plant Physiologists},
  address   = {Rockville},
  issn      = {0032-0889},
  doi       = {10.1104/pp.111.188706},
  pages     = {801 -- 812},
  year      = {2012},
  abstract  = {The cross between Arabidopsis thaliana and the closely related species Arabidopsis arenosa results in postzygotic hybrid incompatibility, manifested as seed death. Ecotypes of A. thaliana were tested for their ability to produce live seed when crossed to A. arenosa. The identified genetic variation was used to map quantitative trait loci (QTLs) encoded by the A. thaliana genome that affect the frequency of postzygotic lethality and the phenotypes of surviving seeds. Seven QTLs affecting the A. thaliana component of this hybrid incompatibility were identified by crossing a Columbia x C24 recombinant inbred line population to diploid A. arenosa pollen donors. Additional epistatic loci were identified based on their pairwise interaction with one or several of these QTLs. Epistatic interactions were detected for all seven QTLs. The two largest additive QTLs were subjected to fine-mapping, indicating the action of at least two genes in each. The topology of this network reveals a large set of minor-effect loci from the maternal genome controlling hybrid growth and viability at different developmental stages. Our study establishes a framework that will enable the identification and characterization of genes and pathways in A. thaliana responsible for hybrid lethality in the A. thaliana x A. arenosa interspecific cross.},
  language  = {en}
}
@article{TorjekWituckaWallMeyeretal.2006,
  author    = {Torjek, Otto and Witucka-Wall, Hanna and Meyer, Rhonda C. and von Korff, Maria and Kusterer, Barbara and Rautengarten, Carsten and Altmann, Thomas},
  title     = {Segregation distortion in Arabidopsis C24/Col-0 and Col-0/C24 recombinant inbred line populations is due to reduced fertility caused by epistatic interaction of two loci},
  series = {Theoretical and applied genetics},
  volume    = {113},
  journal   = {Theoretical and applied genetics},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0040-5752},
  doi       = {10.1007/s00122-006-0402-3},
  pages     = {1551 -- 1561},
  year      = {2006},
  abstract  = {A new large set of reciprocal recombinant inbred lines (RILs) was created between the Arabidopsis accessions Col-0 and C24 for quantitative trait mapping approaches, consisting of 209 Col-0 x C24 and 214 C24 x Col-0 F-7 RI lines. Genotyping was performed using 110 evenly distributed framework single nucleotide polymorphism markers, yielding a genetic map of 425.70 cM, with an average interval of 3.87 cM. Segregation distortion (SD) was observed in several genomic regions during the construction of the genetic map. Linkage disequilibrium analysis revealed an association between a distorted region at the bottom of chromosome V and a non-distorted region on chromosome IV. A detailed analysis of the RILs for these two regions showed that an SD occurred when homozygous Col-0 alleles on chromosome IV coincided with homozygous C24 alleles at the bottom of chromosome V. Using nearly isogenic lines segregating for the distorted region we confirmed that this genotypic composition leads to reduced fertility and fitness.},
  language  = {en}
}