@book{FuhrmannSchubarthSchulzeReicheltetal.2019, author = {Fuhrmann, Michaela and Schubarth, Wilfried and Schulze-Reichelt, Friederike and Mauermeister, Sylvi and Seidel, Andreas and Hartmann, Nina and Erdmann, Melinda and Apostolow, Benjamin and Wagner, Laura and Berndt, Sarah and Wippermann, Melanie and Ratzlaff, Olaf and Lumpe, Matthias and Kirjuchina, Ljuba and Rost, Sophia and Zurek, Peter Paul and Faaß, Marcel and Schellhorn, Sebastian and Frank, Mario and Kreitz, Christoph and Wagner, Nelli and Jenneck, Julia and Kleemann, Katrin and Vock, Miriam and Schr{\"o}der, Christian and Erdmann, Kathrin and Koziol, Matthias and Meißner, Marlen and Dibiasi, Anna and Unger, Martin and Piskunova, Elena V. and Bahmutskiy, Andrey E. and Bessonova, Ekatarina A. and Borovik, Ludmila K.}, title = {Alles auf Anfang!}, series = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, journal = {Potsdamer Beitr{\"a}ge zur Hochschulforschung}, number = {4}, editor = {Schubarth, Wilfried and Mauermeister, Sylvi and Schulze-Reichelt, Friederike and Seidel, Andreas}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-452-4}, issn = {2192-1075}, doi = {10.25932/publishup-42296}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-422965}, publisher = {Universit{\"a}t Potsdam}, pages = {373}, year = {2019}, abstract = {Im Zuge der Bologna-Reform ist an Hochschulen vieles in Bewegung gekommen. Studium und Lehre sind st{\"a}rker ins Blickfeld ger{\"u}ckt. Dabei kommt der Studieneingangsphase besondere Bedeutung zu, werden doch hier die Weichen f{\"u}r ein erfolgreiches Studium gestellt. Deshalb ist es verst{\"a}ndlich, dass die Hauptanstrengungen der Hochschulen auf den Studieneingang gerichtet sind - ganz nach dem Motto: „Auf den Anfang kommt es an!". Konsens herrscht dahingehend, dass der Studieneingang neu zu gestalten ist, doch beim „Wie?" gibt es unterschiedliche Antworten. Zugleich wird immer deutlicher, dass eine wirksame Neugestaltung der Eingangsphase nur mit einer umfassenden Reform des Studiums gelingen kann. Ziel des vierten Bandes der Potsdamer Beitr{\"a}ge zur Hochschulforschung ist es, eine Zwischenbilanz der Debatte zum Studieneingang zu ziehen. Auf der Basis empirischer Studien werden unterschiedliche Perspektiven auf den Studieneingang eingenommen und Empfehlungen zur Optimierung des Studieneingangs abgeleitet. Die zahlreichen Untersuchungsergebnisse Potsdamer Forschergruppen werden durch weitere nationale sowie internationale Perspektiven erg{\"a}nzt. Der Band richtet sich an alle, die sich f{\"u}r die Entwicklung an Hochschulen interessieren.}, language = {de} } @article{HeinrichBuchmannZohseletal.2015, author = {Heinrich, Angela and Buchmann, Arlette F. and Zohsel, Katrin and Dukal, Helene and Frank, Josef and Treutlein, Jens and Nieratschker, Vanessa and Witt, Stephanie H. and Brandeis, Daniel and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Laucht, Manfred and Rietschel, Marcella}, title = {Alterations of Glucocorticoid Receptor Gene Methylation in Externalizing Disorders During Childhood and Adolescence}, series = {Behavior genetics : an international journal devoted to research in the inheritance of behavior in animals and man}, volume = {45}, journal = {Behavior genetics : an international journal devoted to research in the inheritance of behavior in animals and man}, number = {5}, publisher = {Springer}, address = {New York}, issn = {0001-8244}, doi = {10.1007/s10519-015-9721-y}, pages = {529 -- 536}, year = {2015}, abstract = {Epigenetic modulations are a hypothesized link between environmental factors and the development of psychiatric disorders. Research has suggested that patients with depression or bipolar disorder exhibit higher methylation levels in the glucocorticoid receptor gene NR3C1. We aimed to investigate whether NR3C1 methylation changes are similarly associated with externalizing disorders such as aggressive behavior and conduct disorder. NR3C1 exon 1F methylation was analyzed in young adults with a lifetime diagnosis of an externalizing disorder (N = 68) or a depressive disorder (N = 27) and healthy controls (N = 124) from the Mannheim Study of Children at Risk. The externalizing disorders group had significantly lower NR3C1 methylation levels than the lifetime depressive disorder group (p = 0.009) and healthy controls (p = 0.001) This report of lower methylation levels in NR3C1 in externalizing disorders may indicate a mechanism through which the differential development of externalizing disorders as opposed to depressive disorders might occur.}, language = {en} } @misc{WippertPuschmannSchiltenwolfetal.2016, author = {Wippert, Pia-Maria and Puschmann, Anne-Katrin and Schiltenwolf, Marcus and Wiebking, Christine and Mayer, Frank}, title = {BACK PAIN: THE STUDY OF MECHANISMS AND THE TRANSLATION IN INTERVENTIONS WITHIN THE MISPEX NETWORK}, series = {Psychosomatic medicine}, volume = {78}, journal = {Psychosomatic medicine}, publisher = {Elsevier}, address = {Philadelphia}, issn = {0033-3174}, pages = {A91 -- A91}, year = {2016}, language = {en} } @article{FrankFrank2022, author = {Frank, Ulrike and Frank, Katrin}, title = {COVID-19}, series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, volume = {93}, journal = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0028-2804}, doi = {10.1007/s00115-021-01162-5}, pages = {167 -- 174}, year = {2022}, abstract = {Eine COVID-19-Erkrankung kann zu schweren Krankheitsverl{\"a}ufen mit multiplen Organbeteiligungen und respiratorischen und neurologischen Funktionseinschr{\"a}nkungen f{\"u}hren. Schluckst{\"o}rungen (Dysphagien) k{\"o}nnen in dieser Patientengruppe durch prim{\"a}re Sch{\"a}digungen des zentralen und peripheren neuronalen Netzwerkes der Schluckfunktion entstehen, aber auch bedingt durch die h{\"a}ufig l{\"a}ngere intensivmedizinische Behandlung und Beatmung. Erste klinische Befunde zeigen persistierende Dysphagien im Rahmen des Post-COVID-Syndroms („Long-COVID"), sodass die Patienten auch l{\"a}ngerfristige Maßnahmen zur Rehabilitation einer sicheren und suffizienten oralen Nahrungsaufnahme ben{\"o}tigen. Daher sollte in die Behandlung von COVID-19-Patienten ein strukturiertes erkrankungsspezifisches Monitoring in Bezug auf Dysphagiesymptome integriert werden, und atemtherapeutische Maßnahmen zur Regulation von Husteneffektivit{\"a}t und Atem-Schluck-Koordination sollten auch bei diesen Patienten essenzieller Bestandteil des Dysphagiemanagements sein. Herausforderungen ergeben sich dabei einerseits durch die erforderlichen Anpassungen etablierter Behandlungsstandards an den Infektionsschutz. Zudem m{\"u}ssen Auswahl und Durchf{\"u}hrungsintensit{\"a}t therapeutischer Maßnahmen an die Kapazit{\"a}ten und die spezifische Pathophysiologie der COVID-19- und Long-COVID-Patienten angepasst werden, um weitere funktionelle Verschlechterungen zu vermindern.}, language = {de} } @misc{WippertPuschmannDriessleinetal.2017, author = {Wippert, Pia-Maria and Puschmann, Anne-Katrin and Drießlein, David and Arampatzis, Adamantios and Banzer, Winfried and Beck, Heidrun and Schiltenwolf, Marcus and Schmidt, Hendrik and Schneider, Christian and Mayer, Frank}, title = {Development of a risk stratification and prevention index for stratified care in chronic low back pain. Focus: yellow flags (MiSpEx network)}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-403424}, pages = {11}, year = {2017}, abstract = {Introduction: Chronic low back pain (LBP) is a major cause of disability; early diagnosis and stratification of care remain challenges. Objectives: This article describes the development of a screening tool for the 1-year prognosis of patients with high chronic LBP risk (risk stratification index) and for treatment allocation according to treatment-modifiable yellow flag indicators (risk prevention indices, RPI-S). Methods: Screening tools were derived from a multicentre longitudinal study (n = 1071, age >18, intermittent LBP). The greatest prognostic predictors of 4 flag domains ("pain," "distress," "social-environment," "medical care-environment") were determined using least absolute shrinkage and selection operator regression analysis. Internal validity and prognosis error were evaluated after 1-year follow-up. Receiver operating characteristic curves for discrimination (area under the curve) and cutoff values were determined. Results: The risk stratification index identified persons with increased risk of chronic LBP and accurately estimated expected pain intensity and disability on the Pain Grade Questionnaire (0-100 points) up to 1 year later with an average prognosis error of 15 points. In addition, 3-risk classes were discerned with an accuracy of area under the curve = 0.74 (95\% confidence interval 0.63-0.85). The RPI-S also distinguished persons with potentially modifiable prognostic indicators from 4 flag domains and stratified allocation to biopsychosocial treatments accordingly. Conclusion: The screening tools, developed in compliance with the PROGRESS and TRIPOD statements, revealed good validation and prognostic strength. These tools improve on existing screening tools because of their utility for secondary preventions, incorporation of exercise effect modifiers, exact pain estimations, and personalized allocation to multimodal treatments.}, language = {en} } @article{WippertPuschmannDriessleinetal.2017, author = {Wippert, Pia-Maria and Puschmann, Anne-Katrin and Drießlein, David and Arampatzis, Adamantios and Banzer, Winfried and Beck, Heidrun and Schiltenwolf, Marcus and Schmidt, Hendrik and Schneider, Christian and Mayer, Frank}, title = {Development of a risk stratification and prevention index for stratified care in chronic low back pain. Focus: yellow flags (MiSpEx network)}, series = {Pain reports}, volume = {9}, journal = {Pain reports}, publisher = {Wolters Kluwer Health}, address = {Riverwoods, IL}, doi = {10.1097/PR9.0000000000000623}, pages = {1 -- 11}, year = {2017}, abstract = {Introduction: Chronic low back pain (LBP) is a major cause of disability; early diagnosis and stratification of care remain challenges. Objectives: This article describes the development of a screening tool for the 1-year prognosis of patients with high chronic LBP risk (risk stratification index) and for treatment allocation according to treatment-modifiable yellow flag indicators (risk prevention indices, RPI-S). Methods: Screening tools were derived from a multicentre longitudinal study (n = 1071, age >18, intermittent LBP). The greatest prognostic predictors of 4 flag domains ("pain," "distress," "social-environment," "medical care-environment") were determined using least absolute shrinkage and selection operator regression analysis. Internal validity and prognosis error were evaluated after 1-year follow-up. Receiver operating characteristic curves for discrimination (area under the curve) and cutoff values were determined. Results: The risk stratification index identified persons with increased risk of chronic LBP and accurately estimated expected pain intensity and disability on the Pain Grade Questionnaire (0-100 points) up to 1 year later with an average prognosis error of 15 points. In addition, 3-risk classes were discerned with an accuracy of area under the curve = 0.74 (95\% confidence interval 0.63-0.85). The RPI-S also distinguished persons with potentially modifiable prognostic indicators from 4 flag domains and stratified allocation to biopsychosocial treatments accordingly. Conclusion: The screening tools, developed in compliance with the PROGRESS and TRIPOD statements, revealed good validation and prognostic strength. These tools improve on existing screening tools because of their utility for secondary preventions, incorporation of exercise effect modifiers, exact pain estimations, and personalized allocation to multimodal treatments.}, language = {en} } @misc{WippertPuschmannArampatzisetal.2018, author = {Wippert, Pia-Maria and Puschmann, Anne-Katrin and Arampatzis, Adamantios and Schiltenwolf, Marcus and Mayer, Frank}, title = {Diagnosis of psychosocial risk factors in prevention of low back pain in athletes (MiSpEx)}, issn = {1866-8364}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-407391}, year = {2018}, abstract = {Background Low back pain (LBP) is a common pain syndrome in athletes, responsible for 28\% of missed training days/year. Psychosocial factors contribute to chronic pain development. This study aims to investigate the transferability of psychosocial screening tools developed in the general population to athletes and to define athlete-specific thresholds. Methods Data from a prospective multicentre study on LBP were collected at baseline and 1-year follow-up (n=52 athletes, n=289 recreational athletes and n=246 non-athletes). Pain was assessed using the Chronic Pain Grade questionnaire. The psychosocial Risk Stratification Index (RSI) was used to obtain prognostic information regarding the risk of chronic LBP (CLBP). Individual psychosocial risk profile was gained with the Risk Prevention Index - Social (RPI-S). Differences between groups were calculated using general linear models and planned contrasts. Discrimination thresholds for athletes were defined with receiver operating characteristics (ROC) curves. Results Athletes and recreational athletes showed significantly lower psychosocial risk profiles and prognostic risk for CLBP than non-athletes. ROC curves suggested discrimination thresholds for athletes were different compared with non-athletes. Both screenings demonstrated very good sensitivity (RSI=100\%; RPI-S: 75\%-100\%) and specificity (RSI: 76\%-93\%; RPI-S: 71\%-93\%). RSI revealed two risk classes for pain intensity (area under the curve (AUC) 0.92(95\% CI 0.85 to 1.0)) and pain disability (AUC 0.88(95\% CI 0.71 to 1.0)). Conclusions Both screening tools can be used for athletes. Athlete-specific thresholds will improve physicians' decision making and allow stratified treatment and prevention.}, language = {en} } @article{WippertPuschmannArampatzisetal.2017, author = {Wippert, Pia-Maria and Puschmann, Anne-Katrin and Arampatzis, Adamantios and Schiltenwolf, Marcus and Mayer, Frank}, title = {Diagnosis of psychosocial risk factors in prevention of low back pain in athletes (MiSpEx)}, series = {BMJ Open Sport \& Exercise Medicine}, volume = {3}, journal = {BMJ Open Sport \& Exercise Medicine}, number = {1}, issn = {2055-7647}, doi = {10.1136/bmjsem-2017-000295}, year = {2017}, abstract = {Background Low back pain (LBP) is a common pain syndrome in athletes, responsible for 28\% of missed training days/year. Psychosocial factors contribute to chronic pain development. This study aims to investigate the transferability of psychosocial screening tools developed in the general population to athletes and to define athlete-specific thresholds. Methods Data from a prospective multicentre study on LBP were collected at baseline and 1-year follow-up (n=52 athletes, n=289 recreational athletes and n=246 non-athletes). Pain was assessed using the Chronic Pain Grade questionnaire. The psychosocial Risk Stratification Index (RSI) was used to obtain prognostic information regarding the risk of chronic LBP (CLBP). Individual psychosocial risk profile was gained with the Risk Prevention Index - Social (RPI-S). Differences between groups were calculated using general linear models and planned contrasts. Discrimination thresholds for athletes were defined with receiver operating characteristics (ROC) curves. Results Athletes and recreational athletes showed significantly lower psychosocial risk profiles and prognostic risk for CLBP than non-athletes. ROC curves suggested discrimination thresholds for athletes were different compared with non-athletes. Both screenings demonstrated very good sensitivity (RSI=100\%; RPI-S: 75\%-100\%) and specificity (RSI: 76\%-93\%; RPI-S: 71\%-93\%). RSI revealed two risk classes for pain intensity (area under the curve (AUC) 0.92(95\% CI 0.85 to 1.0)) and pain disability (AUC 0.88(95\% CI 0.71 to 1.0)). Conclusions Both screening tools can be used for athletes. Athlete-specific thresholds will improve physicians' decision making and allow stratified treatment and prevention.}, language = {en} } @article{SchleicherMeyerWiegandetal.2011, author = {Schleicher, Jana and Meyer, Katrin M. and Wiegand, Kerstin and Schurr, Frank Martin and Ward, David}, title = {Disentangling facilitation and seed dispersal from environmental heterogeneity as mechanisms generating associations between savanna plants}, series = {Journal of vegetation science}, volume = {22}, journal = {Journal of vegetation science}, number = {6}, publisher = {Wiley-Blackwell}, address = {Malden}, issn = {1100-9233}, doi = {10.1111/j.1654-1103.2011.01310.x}, pages = {1038 -- 1048}, year = {2011}, abstract = {Question: How can we disentangle facilitation and seed dispersal from environmental heterogeneity as mechanisms causing spatial associations of plant species? Location: Semi-arid savanna in the Kimberley Thorn Bushveld, South Africa. Methods: We developed a two-step protocol for the statistical differentiation of association-promoting mechanisms in plants based on the Acacia erioloba-Grewia flava association. Individuals of the savanna shrub G. flava and the tree A. erioloba were mapped on four study plots. Disentangling the mechanism causing the association of G. flava and A. erioloba involved tests of three spatial and one non-spatial null model. The spatial null models include homogeneous and heterogeneous Poisson processes for spatial randomness based on the bivariate spatial point patterns of the four plots. With the non-spatial analysis, we determined the relationship between the canopy diameter of A. erioloba trees and presence or absence of G. flava shrubs in the tree understorey to find whether shrub presence requires a minimum tree canopy diameter. Results: We first showed a significant positive spatial association of the two species. Thereafter, the non-spatial analysis supported an exclusion of environmental heterogeneity as the sole cause of this positive association. We found a minimum tree size under which no G. flava shrubs occurred. Conclusions: Our two-step analysis showed that it is unlikely that heterogeneous environmental conditions caused the spatial association of A. erioloba and G. flava. Instead, this association may have been caused by seed dispersal and/or facilitation (e.g. caused by hydraulic lift and/or nitrogen fixation by the host tree).}, language = {en} } @article{FrankFrankZimmermann2015, author = {Frank, Ulrike and Frank, Katrin and Zimmermann, Heinrich}, title = {Effects of Respiratory Therapy (bagging) on Respiratory Function, Swallowing Frequency and Vigilance in Tracheotomized Patients in Early Neurorehabilitation}, series = {Pneumologie : Zeitschrift f{\"u}r Pneumologie und Beatmungsmedizin}, volume = {69}, journal = {Pneumologie : Zeitschrift f{\"u}r Pneumologie und Beatmungsmedizin}, number = {7}, publisher = {Thieme}, address = {Stuttgart}, issn = {0934-8387}, doi = {10.1055/s-0034-1392359}, pages = {394 -- 399}, year = {2015}, abstract = {Objective: Tracheotomized patients often suffer from impairments in mucociliary clearance and limited capacities for active expectoration of secretions. We investigated the effects of a specific respiratory intervention method (bagging) for tracheotomized patients on respiratory parameters (pO(2), pCO(2), SpO(2), respiratory rates), swallowing frequency, vigilance and secretion viscosity. Methods: The bagging method supports enforced mobilization and expectoration of secretions by application of a series of manual hyperinflations with a resuscitation bag during active inspiration and manual cough support on the chest. 30 tracheotomized neurological patients participated in a multiple-baseline study including a three-weeks intervention period and a follow-up measurement three weeks after termination of the treatment. Results: Most outcome parameters improved significantly during the intervention period: pO(2) (p<.01), SpO(2) (p<.01), respiratory rates (p<.01), swallowing rates (p<.01), and vigilance scores (p<.01). The quality of bronchial secretions improved in all participants. All effects were sustained up to the follow-up measurements. Conclusion: This preliminary data indicates positive effects for a respiratory intervention method (bagging) on respiratory function and additional respiration-related functions in tracheotomized neurological patients. This easy-to-learn and inexpensive method might expand the range of treatment options for tracheotomized and non-responsive patients.}, language = {en} }