@article{LissoSchroederMuessig2013,
  author    = {Lisso, Janina and Schr{\"o}der, Florian and M{\"u}ssig, Carsten},
  title     = {EXO modifies sucrose and trehalose responses and connects the extracellular carbon status to growth},
  series = {Frontiers in plant science},
  volume    = {4},
  journal   = {Frontiers in plant science},
  number    = {25},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-462X},
  doi       = {10.3389/fpls.2013.00219},
  pages     = {18},
  year      = {2013},
  abstract  = {Plants have the capacity to adapt growth to changing environmental conditions. This implies the modulation of metabolism according to the availability of carbon (C). Particular interest in the response to the C availability is based on the increasing atmospheric levels of CO2. Several regulatory pathways that link the C status to growth have emerged. The extracellular EXO protein is essential for cell expansion and promotes shoot and root growth. Homologous proteins were identified in evolutionarily distant green plants. We show here that the EXO protein connects growth with C responses. The exo mutant displayed altered responses to exogenous sucrose supplemented to the growth medium. Impaired growth of the mutant in synthetic medium was associated with the accumulation of starch and anthocyanins, altered expression of sugar-responsive genes, and increased abscisic acid levels. Thus, EXO modulates several responses related to the C availability. Growth retardation on medium supplemented with 2-deoxy-glucose, mannose, and palatinose was similar to the wildtype. Trehalose feeding stimulated root growth and shoot biomass production of exoplants where as it inhibited growth of the wildtype. The phenotypic features of the exo mutant suggest that apoplastic processes coordinate growth and C responses.},
  language  = {en}
}
@misc{SchroederLissoLangeetal.2009,
  author    = {Schr{\"o}der, Florian and Lisso, Janina and Lange, Peggy and M{\"u}ssig, Carsten},
  title     = {The extracellular EXO protein mediates cell expansion in Arabidopsis leaves},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-45107},
  year      = {2009},
  abstract  = {Background: The EXO (EXORDIUM) gene was identified as a potential mediator of brassinosteroid (BR)-promoted growth. It is part of a gene family with eight members in Arabidopsis. EXO gene expression is under control of BR, and EXO overexpression promotes shoot and root growth. In this study, the consequences of loss of EXO function are described. Results: The exo loss of function mutant showed diminished leaf and root growth and reduced biomass production. Light and scanning electron microscopy analyses revealed that impaired leaf growth is due to reduced cell expansion. Epidermis, palisade, and spongy parenchyma cells were smaller in comparison to the wild-type. The exo mutant showed reduced brassinolide-induced cotyledon and hypocotyl growth. In contrast, exo roots were significantly more sensitive to the inhibitory effect of synthetic brassinolide. Apart from reduced growth, exo did not show severe morphological abnormalities. Gene expression analyses of leaf material identified genes that showed robust EXO-dependent expression. Growth-related genes such as WAK1, EXP5, and KCS1, and genes involved in primary and secondary metabolism showed weaker expression in exo than in wild-type plants. However, the vast majority of BR-regulated genes were normally expressed in exo. HA- and GFP-tagged EXO proteins were targeted to the apoplast. Conclusion: The EXO gene is essential for cell expansion in leaves. Gene expression patterns and growth assays suggest that EXO mediates BR-induced leaf growth. However, EXO does not control BR-levels or BR-sensitivity in the shoot. EXO presumably is involved in a signalling process which coordinates BR-responses with environmental or developmental signals. The hypersensitivity of exo roots to BR suggests that EXO plays a diverse role in the control of BR responses in the root.},
  language  = {en}
}
@article{LissoAltmannMuessig2006,
  author    = {Lisso, Janina and Altmann, Thomas and M{\"u}ssig, Carsten},
  title     = {Metabolic changes in fruits of the tomato d(x) mutant},
  series = {Phytochemistry : an international journal of plant biochemistry},
  volume    = {67},
  journal   = {Phytochemistry : an international journal of plant biochemistry},
  number    = {20},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0031-9422},
  doi       = {10.1016/j.phytochem.2006.07.008},
  pages     = {2232 -- 2238},
  year      = {2006},
  language  = {en}
}
@article{LissoAltmannMuessig2006,
  author    = {Lisso, Janina and Altmann, Thomas and M{\"u}ssig, Carsten},
  title     = {The AtNFXL1 gene encodes a NF-X1 type zinc finger protein required for growth under salt stress},
  series = {FEBS letters : the journal for rapid publication of short reports in molecular biosciences},
  volume    = {580},
  journal   = {FEBS letters : the journal for rapid publication of short reports in molecular biosciences},
  number    = {22},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0014-5793},
  doi       = {10.1016/j.febslet.2006.07.079},
  pages     = {4851 -- 4856},
  year      = {2006},
  abstract  = {The human NF-X1 protein and homologous proteins in eukaryotes represent a class of transcription factors which are characterised. by NF-X1 type zinc finger motifs. The Arabidopsis genome encodes two NF-X1 homologs, which we termed AtNFXL1 and AtNFXL2. Growth and survival was impaired in atnfxl1 knock-out mutants and AtNFXL1-antisense plants under salt stress in comparison to wild-type plants. In contrast, 35S: :AtNFXL1 plants showed higher survival rates. The AtNFXL2 protein potentially plays an antagonistic role. The Arabidopsis NF-X1 type zinc finger proteins likely are part of regulatory mechanisms, which protect major processes such as photosynthesis.},
  language  = {en}
}
@phdthesis{Muessig2006,
  author    = {M{\"u}ssig, Carsten},
  title     = {Molekulare Grundlagen der wachstumsf{\"o}rdernden Wirkung der Brassinosteroide},
  address   = {Potsdam},
  pages     = {Getr. Z{\"a}hl. : graph. Darst.},
  year      = {2006},
  language  = {de}
}
@article{MuessigLissoCollGarciaetal.2006,
  author    = {M{\"u}ssig, Carsten and Lisso, Janina and Coll-Garcia, Danahe and Altmann, Thomas},
  title     = {Molecular analysis of brassinosteroid action},
  doi       = {10.1055/s-2005-873043},
  year      = {2006},
  abstract  = {Brassinosteroids (BRs) are steroidal plant hormones with important regulatory roles in various physiological processes, including growth, xylem differentiation, disease resistance, and stress tolerance. Several components of the BR signal transduction pathway have been identified. The extracellular domains of receptor kinases such as BRI1 perceive BRs and transduce the signal via intracellular kinase domains. Within the cell further kinases and phosphatases determine the phosphorylation status of transcription factors such as BES1 and BZR1. These factors mediate major BR effects. Studies of BR-regulated genes shed light on the molecular mode of BR action. Genes encoding cell-wall-modifying enzymes, enzymes of the BR biosynthetic pathway, transcription factors, and proteins involved in primary and secondary metabolism are subject to BR-regulation. Gene expression data also point at interactions with other phytohormones and a role of BR in stress responses. This article gives a survey of the BR-signaling pathway. Two BR-responsive genes, OPR3 and EXO, are described in detail},
  language  = {en}
}
@article{LissoSteinhaeuserAltmannetal.2005,
  author    = {Lisso, Janina and Steinhaeuser, Dirk and Altmann, Thomas and Kopka, Joachim and M{\"u}ssig, Carsten},
  title     = {Identification of brassinosteroid-related genes by means of transcript co-response analyses},
  issn      = {0305-1048},
  year      = {2005},
  abstract  = {The comprehensive systems-biology database (CSB.DB) was used to reveal brassinosteroid (BR)-related genes from expression profiles based on co-response analyses. Genes exhibiting simultaneous changes in transcript levels are candidates of common transcriptional regulation. Combining numerous different experiments in data matrices allows ruling out outliers and conditional changes of transcript levels. CSB.DB was queried for transcriptional co-responses with the BR-signalling components BRI1 and BAK1: 301 out of 9694 genes represented in the nasc0271 database showed co-responses with both genes. As expected, these genes comprised pathway-involved genes (e.g. 72 BR-induced genes), because the BRI1 and BAK1 proteins are required for BR-responses. But transcript co-response takes the analysis a step further compared with direct approaches because BR-related non BR-responsive genes were identified. Insights into networks and the functional context of genes are provided, because factors determining expression patterns are reflected in correlations. Our findings demonstrate that transcript co-response analysis presents a valuable resource to uncover common regulatory patterns of genes. Different data matrices in CSB.DB allow examination of specific biological questions. All matrices are publicly available through CSB.DB. This work presents one possible roadmap to use the CSB.DB resources},
  language  = {en}
}
@article{MeyerMuessigAltmann2004,
  author    = {Meyer, Rhonda C. and M{\"u}ssig, Carsten and Altmann, Thomas},
  title     = {Genetic Diversity : Creation of novel genetic variants of arabidopsis},
  isbn      = {3-00-011587-0},
  year      = {2004},
  language  = {en}
}
@article{GollGarciaMazuchAltmannetal.2004,
  author    = {Goll-Garcia, D. and Mazuch, J. and Altmann, Thomas and M{\"u}ssig, Carsten},
  title     = {Exordium regulates brassinosteroid-responsive genes},
  year      = {2004},
  abstract  = {In a screen for potential mediators of brassinosteroid (BR) effects, the EXORDIUM (EXO) protein was identified as a regulator of BR-responsive genes. The EXO gene was characterized as a BR-up-regulated gene. EXO overexpression under the control of the 35SCaMV promoter resulted in increased transcript levels of the BR-up-regulated KCS1, Exp5, delta-TIP, and AGP4 genes, which likely are involved in the mediation of BR-promoted growth. 35S::EXO lines grown in soil or in synthetic medium showed increased vegetative growth in comparison to wild-type plants, resembling the growth phenotype of BR-treated plants. Thus, the EXO protein most likely promotes growth via the modulation of gene expression patterns. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved},
  language  = {en}
}
@article{AltmannToerjekBergeretal.2003,
  author    = {Altmann, Thomas and T{\"o}rjek, Otto and Berger, Dieter and Meyer, Rhonda C. and M{\"u}ssig, Carsten and Schmidt, K. J. and Sorensen, T. R. and Weisshaar, Bernd and Olds-Mitchell, T.},
  title     = {Establishment of a high-efficiency SNP-based framework marker set for Arabidopsis},
  year      = {2003},
  language  = {en}
}